{"id":9627,"date":"2026-11-03T00:30:51","date_gmt":"2026-11-02T23:30:51","guid":{"rendered":"https:\/\/www.s-vt.net\/?page_id=9627"},"modified":"2026-11-03T00:30:51","modified_gmt":"2026-11-02T23:30:51","slug":"active-ingredients","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/ar\/active-ingredients\/","title":{"rendered":"Active Ingredients"},"content":{"rendered":"<div style='' class=''><section class='page-content' style=''  ><section class='container'><div style='' class=''><div class='row' style=''><div style='' class=''><div class='col-md-12 ' style=''><div style='' class=''><div class='cma-wysiwyg-editor'><p class=\"svt-lead2\">The production of active ingredients involves operations that must be precise, fast, efficient and at the same time gentle. A conventional agitator alone cannot handle this task.<\/p><div class=\"svt-ptiles\"><div class=\"svt-ptile\"><i class=\"fa fa-cogs\" aria-hidden=\"true\"><\/i><strong>Rotor\/stator system<\/strong><span>Reduce solids in size and increase the powder surface area.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-sliders\" aria-hidden=\"true\"><\/i><strong>Variable process parameters<\/strong><span>Infinitely variable speed for agitator and homogeniser.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-plus-square\" aria-hidden=\"true\"><\/i><strong>Expandable<\/strong><span>Plants that grow with new requirements.<\/span><\/div><\/div><h2>High-performance agitating and homogenising systems<\/h2><p>This is why process plants with integrated, powerful agitating and homogenising systems are used. Their rotor\/stator system ensures optimum size reduction of the solids while increasing the surface area of the powder in the liquid. This produces agglomerate-free solutions within a few minutes.<\/p><p>Breaking up the <a href=\"\/en\/api-deagglomeration\/\">agglomerates<\/a> makes the entire particle surface accessible to the liquid. As a result, active ingredients dissolve more quickly and evenly, <a href=\"\/en\/suspensions\/\">suspensions<\/a> become more homogeneous, and dosing accuracy increases.<\/p><p class=\"svt-knote\">For poorly soluble active ingredients, a finer particle size can improve the dissolution rate and thus the bioavailability. For true micronisation down to a few micrometres, however, jet mills, bead mills or high-pressure homogenisers are usually used. The rotor\/stator homogeniser mainly takes care of deagglomerating, wetting and dispersing.<\/p><h2>Requirements for the plant<\/h2><ul class=\"svt-checks\"><li>Variable setting of the process parameters<\/li><li>Infinitely variable speed adjustment of agitator and homogeniser for efficient <a href=\"\/en\/agitation\/\">stirring<\/a> and <a href=\"\/en\/homogenisation\/\">homogenising<\/a> in all speed ranges<\/li><li>Simple expansion in line with new developments and requirements<\/li><\/ul><h2>FAQ: Processing active ingredients<\/h2><h3>What requirements does active ingredient processing place on the plant?<\/h3><p>Precise, fast, efficient and at the same time gentle processes: high shear for dispersing, variable speeds, exact temperature control, GMP design as well as CIP and SIP.<\/p><h3>Why are homogenising mixers used instead of simple agitators?<\/h3><p>Only the rotor-stator system generates the shear forces needed to reduce solids in size, break up agglomerates and distribute active ingredients evenly.<\/p><h3>How does particle size influence efficacy?<\/h3><p>Smaller particles have a larger surface area and dissolve faster. This can improve bioavailability and reduce the amount of active ingredient required.<\/p><h3>How are sensitive active ingredients protected?<\/h3><p>Through infinitely adjustable speeds, controlled energy input, temperature control and working under vacuum or inert gas.<\/p><h3>How does SEEFRIED support manufacturers of active ingredients?<\/h3><p>With process consulting, plant planning, qualification and inspected used homogenising mixers.<\/p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Prozessanlagen f\u00fcr die Wirkstoffverarbeitung\",\"description\":\"Verfahrensberatung, Planung und Homogenisiermischer f\u00fcr die pr\u00e4zise, schonende Verarbeitung pharmazeutischer Wirkstoffe (API).\",\"url\":\"https:\/\/www.s-vt.net\/en\/active-ingredients\/\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What requirements does active ingredient processing place on the plant?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Precise, fast, efficient and at the same time gentle processes: high shear for dispersing, variable speeds, exact temperature control, GMP design as well as CIP and SIP.\"}},{\"@type\":\"Question\",\"name\":\"Why are homogenising mixers used instead of simple agitators?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Only the rotor-stator system generates the shear forces needed to reduce solids in size, break up agglomerates and distribute active ingredients evenly.\"}},{\"@type\":\"Question\",\"name\":\"How does particle size influence efficacy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Smaller particles have a larger surface area and dissolve faster. This can improve bioavailability and reduce the amount of active ingredient required.\"}},{\"@type\":\"Question\",\"name\":\"How are sensitive active ingredients protected?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Through infinitely adjustable speeds, controlled energy input, temperature control and working under vacuum or inert gas.\"}},{\"@type\":\"Question\",\"name\":\"How does SEEFRIED support manufacturers of active ingredients?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"With process consulting, plant planning, qualification and inspected used homogenising mixers.\"}}]}]}<\/script><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"class_list":["post-9627","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Processing Active Ingredients: Mixers | SEEFRIED<\/title>\n<meta name=\"description\" content=\"Process active pharmaceutical ingredients (API) precisely and gently: rotor-stator homogenisation, deagglomeration, GMP design. 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