{"id":9629,"date":"2026-11-03T00:31:05","date_gmt":"2026-11-02T23:31:05","guid":{"rendered":"https:\/\/www.s-vt.net\/?page_id=9629"},"modified":"2026-11-03T00:31:05","modified_gmt":"2026-11-02T23:31:05","slug":"api-deagglomeration","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/","title":{"rendered":"API Deagglomeration"},"content":{"rendered":"<div style='' class=''><section class='page-content' style=''  ><section class='container'><div style='' class=''><div class='row' style=''><div style='' class=''><div class='col-md-12 ' style=''><div style='' class=''><div class='cma-wysiwyg-editor'><p class=\"svt-lead2\">In the manufacture of pharmaceutical products, the preliminary stages frequently produce <a href=\"\/en\/agglomeration\/\">agglomerates<\/a> \u2013 especially with mixtures of powders and liquids. For the further process, these lumps must be broken up and the raw materials reduced in size; this process is called API deagglomeration.<\/p><div class=\"svt-ptiles\"><div class=\"svt-ptile\"><i class=\"fa fa-cogs\" aria-hidden=\"true\"><\/i><strong>Rotor\/stator system<\/strong><span>Optimum size reduction of solids in the liquid.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-clock-o\" aria-hidden=\"true\"><\/i><strong>Within a few minutes<\/strong><span>Agglomerate-free solutions in a short time.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-bullseye\" aria-hidden=\"true\"><\/i><strong>Higher dosing accuracy<\/strong><span>More homogeneous suspensions and faster-dissolving active ingredients.<\/span><\/div><\/div><h2>Why an agitator alone is not enough<\/h2><p>A conventional agitator cannot reliably break up agglomerates. Modern process plants with integrated, powerful agitating and <a href=\"\/en\/homogenisation\/\">homogenising systems<\/a> are, by contrast, ideally suited to this.<\/p><p>Their rotor\/stator system reduces the solids in size optimally while increasing the surface area of the powder in the liquid. This produces agglomerate-free solutions within a few minutes.<\/p><h2>Advantages of API deagglomeration<\/h2><p>Breaking up the agglomerates makes the entire particle surface accessible to the liquid. This brings several advantages:<\/p><ul class=\"svt-checks\"><li>Active ingredients dissolve more quickly and evenly<\/li><li><a href=\"\/en\/suspensions\/\">Suspensions<\/a> become more homogeneous<\/li><li>Dosing accuracy increases<\/li><li>For poorly soluble active ingredients, a finer particle size can improve the dissolution rate and thus the bioavailability<\/li><\/ul><p class=\"svt-knote\">For true micronisation down to a few micrometres, jet mills, bead mills or high-pressure homogenisers are usually used. The rotor\/stator homogeniser mainly takes care of deagglomerating, wetting and <a href=\"\/en\/dispersion\/\">dispersing<\/a>.<\/p><h2>FAQ: API deagglomeration<\/h2><h3>What is API deagglomeration?<\/h3><p>Breaking up agglomerates and lumps that form when powdered active ingredients are mixed with liquids. The aim is a fine, even distribution of every single particle.<\/p><h3>Why is a normal agitator not sufficient?<\/h3><p>An agitator generates hardly any shear forces. Agglomerates remain and powder nests form. Only the high shear in the rotor-stator gap of a homogeniser breaks them up reliably.<\/p><h3>What are the benefits of good deagglomeration?<\/h3><p>Shorter dissolving and process times, homogeneous distribution of active ingredients, higher dosing accuracy and a larger effective particle surface, which can improve dissolution rate and bioavailability.<\/p><h3>How are powders best incorporated?<\/h3><p>By vacuum powder induction directly into the shear zone of the homogeniser below the liquid level, so that every particle is wetted immediately.<\/p><h3>Does SEEFRIED offer solutions for deagglomeration?<\/h3><p>Yes, with process consulting, trial planning and suitable homogenising mixers, including used ones.<\/p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Wirkstoffdeagglomeration mit Homogenisiermischern\",\"description\":\"Verfahrensberatung und Homogenisiermischer zur zuverl\u00e4ssigen Deagglomeration pulverf\u00f6rmiger Wirkstoffe in Fl\u00fcssigkeiten.\",\"url\":\"https:\/\/www.s-vt.net\/en\/api-deagglomeration\/\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is API deagglomeration?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Breaking up agglomerates and lumps that form when powdered active ingredients are mixed with liquids. The aim is a fine, even distribution of every single particle.\"}},{\"@type\":\"Question\",\"name\":\"Why is a normal agitator not sufficient?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"An agitator generates hardly any shear forces. Agglomerates remain and powder nests form. Only the high shear in the rotor-stator gap of a homogeniser breaks them up reliably.\"}},{\"@type\":\"Question\",\"name\":\"What are the benefits of good deagglomeration?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Shorter dissolving and process times, homogeneous distribution of active ingredients, higher dosing accuracy and a larger effective particle surface, which can improve dissolution rate and bioavailability.\"}},{\"@type\":\"Question\",\"name\":\"How are powders best incorporated?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"By vacuum powder induction directly into the shear zone of the homogeniser below the liquid level, so that every particle is wetted immediately.\"}},{\"@type\":\"Question\",\"name\":\"Does SEEFRIED offer solutions for deagglomeration?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes, with process consulting, trial planning and suitable homogenising mixers, including used ones.\"}}]}]}<\/script><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"class_list":["post-9629","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>API Deagglomeration: Breaking Up Agglomerates | SEEFRIED<\/title>\n<meta name=\"description\" content=\"API deagglomeration with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"API Deagglomeration: Breaking Up Agglomerates | SEEFRIED\" \/>\n<meta property=\"og:description\" content=\"API deagglomeration with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/\" \/>\n<meta property=\"og:site_name\" content=\"SEEFRIED Verfahrenstechnik GmbH\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/ar\\\/api-deagglomeration\\\/\",\"url\":\"https:\\\/\\\/www.s-vt.net\\\/ar\\\/api-deagglomeration\\\/\",\"name\":\"API Deagglomeration: Breaking Up Agglomerates | SEEFRIED\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/#website\"},\"datePublished\":\"2026-11-02T23:31:05+00:00\",\"description\":\"API deagglomeration with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/ar\\\/api-deagglomeration\\\/#breadcrumb\"},\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.s-vt.net\\\/ar\\\/api-deagglomeration\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/ar\\\/api-deagglomeration\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/www.s-vt.net\\\/ar\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"API Deagglomeration\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/#website\",\"url\":\"https:\\\/\\\/www.s-vt.net\\\/\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"description\":\"\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u062e\u0644\u0637 \u0648\u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0639\u0644\u0649 \u0623\u064a\u062f\u064a \u062e\u0628\u0631\u0627\u0621\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.s-vt.net\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ar\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"API Deagglomeration: Breaking Up Agglomerates | SEEFRIED","description":"API deagglomeration with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/","og_locale":"ar_AR","og_type":"article","og_title":"API Deagglomeration: Breaking Up Agglomerates | SEEFRIED","og_description":"API deagglomeration with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction.","og_url":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/","og_site_name":"SEEFRIED Verfahrenstechnik GmbH","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/","url":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/","name":"API Deagglomeration: Breaking Up Agglomerates | SEEFRIED","isPartOf":{"@id":"https:\/\/www.s-vt.net\/#website"},"datePublished":"2026-11-02T23:31:05+00:00","description":"API deagglomeration with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction.","breadcrumb":{"@id":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/#breadcrumb"},"inLanguage":"ar","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.s-vt.net\/ar\/api-deagglomeration\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/www.s-vt.net\/ar\/"},{"@type":"ListItem","position":2,"name":"API Deagglomeration"}]},{"@type":"WebSite","@id":"https:\/\/www.s-vt.net\/#website","url":"https:\/\/www.s-vt.net\/","name":"SEEFRIED Verfahrenstechnik GmbH","description":"\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u062e\u0644\u0637 \u0648\u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0639\u0644\u0649 \u0623\u064a\u062f\u064a \u062e\u0628\u0631\u0627\u0621","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.s-vt.net\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ar"}]}},"_links":{"self":[{"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/pages\/9629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/comments?post=9629"}],"version-history":[{"count":1,"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/pages\/9629\/revisions"}],"predecessor-version":[{"id":9630,"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/pages\/9629\/revisions\/9630"}],"wp:attachment":[{"href":"https:\/\/www.s-vt.net\/ar\/wp-json\/wp\/v2\/media?parent=9629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}