{"id":3991,"date":"2016-05-03T10:10:21","date_gmt":"2016-05-03T08:10:21","guid":{"rendered":"http:\/\/mirror.s-vt.net\/wirkstoffdeagglomeration\/"},"modified":"2026-10-26T15:14:15","modified_gmt":"2026-10-26T14:14:15","slug":"active-substance-deagglomeration","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/en\/active-substance-deagglomeration\/","title":{"rendered":"Deagglomeration of Active Substances"},"content":{"rendered":"<section class='page-content' style=''  ><section class='container'><div class='row' style=''><div class='col-md-12 ' style=''><div class='cma-wysiwyg-editor'><p class=\"svt-lead2\">In pharmaceutical production, <a href=\"\/agglomeration\/?lang=en\">agglomerates<\/a> often form in the preliminary stages \u2013 especially in mixtures of powders and liquids. For the further process, these lumps must be broken up and the raw materials reduced in size; this process is called active substance deagglomeration.<\/p><div class=\"svt-ptiles\"><div class=\"svt-ptile\"><i class=\"fa fa-cogs\" aria-hidden=\"true\"><\/i><strong>Rotor\/stator system<\/strong><span>Optimal size reduction of solids in the liquid.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-clock-o\" aria-hidden=\"true\"><\/i><strong>Within minutes<\/strong><span>Agglomerate-free solutions in a short time.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-bullseye\" aria-hidden=\"true\"><\/i><strong>Higher dosing accuracy<\/strong><span>More homogeneous suspensions and faster-dissolving active ingredients.<\/span><\/div><\/div><h2>Why an agitator alone is not enough<\/h2><p>A conventional agitator cannot reliably break up agglomerates. Modern process plants with integrated, powerful agitation and <a href=\"\/homogenisation\/?lang=en\">homogenising systems<\/a>, on the other hand, are ideally suited to this task.<\/p><p>Their rotor\/stator system reduces solids optimally and at the same time increases the surface area of the powder in the liquid. This produces agglomerate-free solutions within a few minutes.<\/p><h2>Benefits of active substance deagglomeration<\/h2><p>Breaking up the agglomerates makes the entire particle surface accessible to the liquid. This brings several advantages:<\/p><ul class=\"svt-checks\"><li>active ingredients dissolve faster and more evenly<\/li><li><a href=\"\/suspensions\/?lang=en\">suspensions<\/a> become more homogeneous<\/li><li>dosing accuracy increases<\/li><li>for poorly soluble active ingredients, a finer particle size can improve the dissolution rate and thus bioavailability<\/li><\/ul><p class=\"svt-knote\">True micronisation down to a few micrometres usually requires jet mills, bead mills or high-pressure homogenisers. The rotor\/stator homogeniser mainly handles deagglomeration, wetting and <a href=\"\/dispersion\/?lang=en\">dispersion<\/a>.<\/p><h2>FAQ: Active substance deagglomeration<\/h2><h3>What is active substance deagglomeration?<\/h3><p>Breaking up agglomerates and lumps that form when powdered actives are mixed with liquids. The goal is a fine, uniform distribution of every single particle.<\/p><h3>Why is a standard agitator not sufficient?<\/h3><p>An agitator produces hardly any shear. Agglomerates remain and powder nests form. Only the high shear in the rotor-stator gap of a homogeniser breaks them up reliably.<\/p><h3>What are the benefits of good deagglomeration?<\/h3><p>Shorter dissolving and process times, homogeneous active distribution, higher dosing accuracy and a larger effective particle surface, which can improve dissolution rate and bioavailability.<\/p><h3>How are powders best incorporated?<\/h3><p>By vacuum powder induction directly into the shear zone of the homogeniser below the liquid level, so every particle is wetted immediately.<\/p><h3>Does SEEFRIED offer deagglomeration solutions?<\/h3><p>Yes, with process consulting, trial planning and suitable homogenising mixers, also used.<\/p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Active substance deagglomeration with homogenising mixers\",\"description\":\"Process consulting and homogenising mixers for reliable deagglomeration of powdered actives in liquids.\",\"url\":\"https:\/\/www.s-vt.net\/active-substance-deagglomeration\/?lang=en\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is active substance deagglomeration?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Breaking up agglomerates and lumps that form when powdered actives are mixed with liquids. 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Only the high shear in the rotor-stator gap of a homogeniser breaks them up reliably.\"}},{\"@type\":\"Question\",\"name\":\"What are the benefits of good deagglomeration?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Shorter dissolving and process times, homogeneous active distribution, higher dosing accuracy and a larger effective particle surface, which can improve dissolution rate and bioavailability.\"}},{\"@type\":\"Question\",\"name\":\"How are powders best incorporated?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"By vacuum powder induction directly into the shear zone of the homogeniser below the liquid level, so every particle is wetted immediately.\"}},{\"@type\":\"Question\",\"name\":\"Does SEEFRIED offer deagglomeration solutions?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes, with process consulting, trial planning and suitable homogenising mixers, also used.\"}}]}]}<\/script><\/div><\/div><\/div><\/section><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"class_list":["post-3991","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Active Substance Deagglomeration | SEEFRIED<\/title>\n<meta name=\"description\" content=\"Deagglomerating actives with rotor-stator homogenisers: agglomerate-free solutions and suspensions in minutes, vacuum powder induction. 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