{"id":3995,"date":"2016-05-03T10:06:00","date_gmt":"2016-05-03T08:06:00","guid":{"rendered":"http:\/\/mirror.s-vt.net\/suppositorien\/"},"modified":"2026-10-26T15:13:35","modified_gmt":"2026-10-26T14:13:35","slug":"suppositories","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/en\/suppositories\/","title":{"rendered":"Suppositories"},"content":{"rendered":"

Suppositories are divided into fat-based and water-soluble preparations. Fat-based suppositories are the better-known form.<\/p>

<\/i>Precise temperature control<\/strong>Infinitely adjustable heating and cooling of all product-contact parts.<\/span><\/div>
<\/i>Circulation agitator<\/strong>Intensive mixing with minimal shear if required.<\/span><\/div>
<\/i>Complete documentation<\/strong>All production steps are recorded and stored.<\/span><\/div><\/div>

Fat-based and water-soluble suppositories<\/h2>
<\/i>

Fat-based<\/h3>

The base is usually hard fat with a melting range close to body temperature. This allows the suppository to dissolve at the site of application. The hard fat therefore needs defined emulsifying and melting properties.<\/p><\/div>

<\/i>

Water-soluble<\/h3>

These suppositories do not melt but dissolve in the water present and then release the active ingredient. Mixtures of different polyethylene glycols (macrogol) as well as gelatine and glycerol are used.<\/p><\/div><\/div>

One challenge with water-soluble suppositories is the small amount of liquid at the site of application, for example in the rectum, in which the suppository has to dissolve.<\/p>

Suppositories are made from emulsions<\/a>, suspensions<\/a> or solutions of various active ingredients<\/a> and hard fats.<\/p>

Requirements for the homogenising mixer<\/h2>

In addition to hygienic production, handling very different viscosities is crucial. Modern homogenising mixers can be used flexibly and efficiently for this:<\/p>