{"id":4014,"date":"2015-05-04T12:07:03","date_gmt":"2015-05-04T12:07:03","guid":{"rendered":"http:\/\/mirror.s-vt.net\/cip-sip-systeme\/"},"modified":"2026-10-26T09:59:04","modified_gmt":"2026-10-26T08:59:04","slug":"cip-sip-systems","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/en\/cip-sip-systems\/","title":{"rendered":"CIP\/SIP Systems"},"content":{"rendered":"<section class='page-content' style=''  ><section class='container'><div class='row' style=''><div class='col-md-12 ' style=''><div class='cma-wysiwyg-editor'><p class=\"svt-lead2\">The CIP process (Cleaning in Place) comprises mechanical and chemical processes that are mainly used in the <a href=\"\/pharmacy\/?lang=en\">pharmaceutical<\/a>, <a href=\"\/cosmetics\/?lang=en\">cosmetics<\/a> and food industries. Vessels, pipes and valves are cleaned on all product-contact surfaces between production runs \u2013 without prior dismantling.<\/p><div class=\"svt-ptiles\"><div class=\"svt-ptile\"><i class=\"fa fa-refresh\" aria-hidden=\"true\"><\/i><strong>Cleaning without dismantling<\/strong><span>Vessels, pipes and valves are cleaned in their installed state.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-fire\" aria-hidden=\"true\"><\/i><strong>Sterilisation with pure steam<\/strong><span>SIP sterilises all product-contact plant parts, typically at 121 \u00b0C.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-check-square-o\" aria-hidden=\"true\"><\/i><strong>Reproducible &amp; documented<\/strong><span>Fully automatic sequences with complete documentation of the cleaning process.<\/span><\/div><\/div><p>Practical experience and tests show that the mechanical cleaning effect depends on the flow velocity and turbulence of the cleaning liquid. In addition, the temperature and concentration of the cleaning solution influence the cleaning speed. Therefore, these factors should already be defined when designing a cleaning system.<\/p><h2>Product safety, hygiene and efficiency<\/h2><p>The CIP process plays a central role in product safety and hygiene. At the same time, the plant should run as efficiently as possible with minimal downtime. Rising costs for water and energy are particularly important here, as is a chemical consumption that is matched to the respective products.<\/p><p>Anyone developing cleaning processes therefore needs to know the properties of the excipients and active ingredients and select a suitable cleaning agent. An unsuitable cleaning agent can significantly extend cleaning times or even prevent complete cleaning.<\/p><p>How thorough a cleaning is depends on many factors. Besides the type of soiling, these include the condition of the product-contact surfaces and their installations. Corners, edges, seal arrangements and low-flow zones \u2013 for example in T-pieces, puddles or domes \u2013 are just as decisive, as are the operating conditions.<\/p><h2>What cleaning effectiveness depends on<\/h2><ul class=\"svt-checks\"><li>design measures in the plant areas to be cleaned (<a href=\"\/design-qualification\/?lang=en\">GMP \u2013 Good Manufacturing Practice<\/a>)<\/li><li>suitable choice and quality of materials<\/li><li>suitable cleaning agents<\/li><li>correct cleaning conditions<\/li><\/ul><div class=\"svt-kgrid svt-kgrid-2\"><div class=\"svt-kcard\"><i class=\"fa fa-sliders\" aria-hidden=\"true\"><\/i><h3>Key features of CIP cleaning<\/h3><ul class=\"svt-klist\"><li>flow velocity in pipes and valves (1\u20134 m\/s depending on pipe cross-section)<\/li><li>duration of rinsing<\/li><li>spray pressure at the cleaning heads<\/li><li>temperature of the cleaning solutions<\/li><li>alkaline rinsing solutions with additives that keep dirt particles in suspension (preferably non-foaming)<\/li><li>acid rinses against deposits such as limescale after alkaline cleaning<\/li><li>disinfection (SIP or chemical)<\/li><li>contact time and temperature of the cleaning agents<\/li><li>size of the plant<\/li><li>reproducible process through fully automatic sequences<\/li><li>documentation of the cleaning process<\/li><\/ul><\/div><div class=\"svt-kcard\"><i class=\"fa fa-bullseye\" aria-hidden=\"true\"><\/i><h3>Purpose of CIP\/SIP cleaning<\/h3><ul class=\"svt-klist\"><li>complete removal of product residues<\/li><li>removal of biofilms<\/li><li>no cleaning agent residues<\/li><li>sterility of plant parts and pipes<\/li><\/ul><\/div><\/div><h2>CIP cleaning sequence in the pharmaceutical industry<\/h2><ol class=\"svt-steps\"><li><span class=\"svt-step-n\">1<\/span><strong>Pressure hold test<\/strong><span class=\"svt-step-tx\">First, the plant is checked for leaks.<\/span><\/li><li><span class=\"svt-step-n\">2<\/span><strong>Evacuate and melt off<\/strong><span class=\"svt-step-tx\">For greasy products, the plant is evacuated, product residues are melted off with pure steam and drained in concentrated form.<\/span><\/li><li><span class=\"svt-step-n\">3<\/span><strong>Hot pre-rinse<\/strong><span class=\"svt-step-tx\">A hot pre-rinse removes coarse soiling.<\/span><\/li><li><span class=\"svt-step-n\">4<\/span><strong>Alkaline cleaning<\/strong><span class=\"svt-step-tx\">Cleaning with an <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cleaning_agent\" target=\"_blank\" rel=\"noopener\">alkaline agent<\/a>, if necessary with additives that keep dirt particles in suspension.<\/span><\/li><li><span class=\"svt-step-n\">5<\/span><strong>Hot rinse<\/strong><span class=\"svt-step-tx\">During draining, cleaning agent and product residues are rinsed out.<\/span><\/li><li><span class=\"svt-step-n\">6<\/span><strong>Rinse with purified water<\/strong><span class=\"svt-step-tx\">Next, the plant is rinsed with purified water during draining.<\/span><\/li><li><span class=\"svt-step-n\">7<\/span><strong>Acid cleaning<\/strong><span class=\"svt-step-tx\">An acid agent removes limescale and caustic scale.<\/span><\/li><li><span class=\"svt-step-n\">8<\/span><strong>Rinse with purified water again<\/strong><span class=\"svt-step-tx\">The plant is then rinsed once more with purified water.<\/span><\/li><li><span class=\"svt-step-n\">9<\/span><strong>SIP \u2013 Sterilization in Place<\/strong><span class=\"svt-step-tx\">Evacuate the plant section, control the steam pressure up to the overpressure range and drain the condensate.<\/span><\/li><li><span class=\"svt-step-n\">10<\/span><strong>Drying<\/strong><span class=\"svt-step-tx\">Finally, the plant is dried under vacuum, e.g. with hot, sterile supply air.<\/span><\/li><\/ol><p class=\"svt-knote\">The sequence and step times can be adjusted. The concentration of the cleaning medium is also variable. In addition, the detergent concentrates can be combined in a fresh batch to form an optimally effective cleaning solution (stacked cleaning).<\/p><h2>Sterilization in Place (SIP)<\/h2><p>Sterilization in Place is the in-situ sterilisation of process plants with pure steam. Here, too, no dismantling is necessary. All components that come into contact with the product are sterilised.<\/p><p>The SIP process usually works with saturated pure steam. A sterilisation temperature of 121 \u00b0C requires an overpressure of about 1 bar. Depending on the requirements, the temperature is controlled and documented as a function of steam pressure and exposure time.<\/p><p>The plant parts to be sterilised should be evacuated before steam sterilisation. In this way, no air pockets form and the temperature distributes quickly and evenly.<\/p><h2>CIP systems integrated into process plants<\/h2><p>All internal surfaces of the process plant are primarily cleaned in the cleaning-in-place process. The homogeniser serves as the conveying unit for the CIP solution. Further equipment includes, for example:<\/p><ul class=\"svt-checks\"><li>suction hose for liquids<\/li><li>suction lance for powders<\/li><li>phase vessels<\/li><\/ul><p>The mixing plant should be designed so that as much product as possible reaches the target vessels. This also includes the inlet of a filling machine. As a result, little residual product remains and only a minimal amount enters the waste water.<\/p><p>The vessel bottom, wall scrapers and surface as well as the length and slope of the discharge line behind the homogeniser should therefore be designed so that, as far as possible, no residues remain. Furthermore, all pipes within the process plant belong in the CIP process.<\/p><p>Additional equipment for the CIP process must not be a source of physical, chemical or microbiological contamination. Moreover, air gaps in front of all waste water connections prevent recontamination.<\/p><h2>Cleaning process in cosmetics plants<\/h2><p>The CIP process in cosmetics plants usually consists of the following steps:<\/p><ol class=\"svt-steps\"><li><span class=\"svt-step-n\">1<\/span><strong>Hot flush<\/strong><span class=\"svt-step-tx\">Plant parts and pipes are flushed with hot water in a single pass. This way, product residues go directly into the waste water without soiling the CIP equipment.<\/span><\/li><li><span class=\"svt-step-n\">2<\/span><strong>Alkaline cleaning<\/strong><span class=\"svt-step-tx\">A caustic solution at approx. 70 \u00b0C is circulated and removes all visible product residues. The vessel is then rinsed during draining.<\/span><\/li><li><span class=\"svt-step-n\">3<\/span><strong>Acid cleaning and disinfection<\/strong><span class=\"svt-step-tx\">An acid agent dissolves limescale. Hot water then circulates until the equipment reaches 80\u201390 \u00b0C for a defined period (thermal disinfection).<\/span><\/li><li><span class=\"svt-step-n\">4<\/span><strong>Cold final rinse<\/strong><span class=\"svt-step-tx\">Finally, the plant is rinsed with cold DI water in circulation via spray heads and rinsed again during draining.<\/span><\/li><\/ol><p>These steps can follow one another, be repeated or be skipped \u2013 with or without additional cleaning agents.<\/p><p class=\"svt-knote\">Optionally, a conductivity sensor monitors the cleaning quality (final rinse water &lt; 50 \u00b5S\/cm at 20 \u00b0C).<\/p><p><strong>SEEFRIED Verfahrenstechnik GmbH<\/strong> supports you in the design of CIP and SIP systems, the CIP procedures and the procurement of the associated process equipment.<\/p><h2>Frequently Asked Questions about CIP and SIP systems<\/h2>\n<h3>What is the difference between CIP and SIP?<\/h3>\n<p>CIP (Cleaning in Place) cleans vessels, pipelines and valves without dismantling. SIP (Sterilization in Place) then sterilizes the product-contact parts \u2013 also without dismantling \u2013 using pure steam, typically at 121 \u00b0C.<\/p>\n<h3>Which factors determine cleaning success?<\/h3>\n<p>Key factors are flow velocity (approx. 1\u20134 m\/s in pipelines), temperature, concentration and contact time of the cleaning solution, spray pressure at the cleaning heads, the right detergent and a hygienic design without low-flow zones.<\/p>\n<h3>What does a typical CIP sequence look like?<\/h3>\n<p>Common steps are hot pre-rinsing, cleaning with an alkaline agent, intermediate rinsing, cleaning with an acidic agent against lime scale and final rinsing with purified water \u2013 followed by SIP and drying if required. Sequence and step times can be adapted.<\/p>\n<h3>How is cleaning success verified?<\/h3>\n<p>For example with a conductivity sensor in the final rinse water (guide value &lt; 50 \u00b5S\/cm at 20 \u00b0C). Fully automated, documented sequences ensure reproducible results.<\/p>\n<p><h2 class=\"svt-pcta-h\">Talk to us<\/h2><div class=\"svt-pcta svt-pcta-m\"><div class=\"svt-pcta-tx\">We are happy to advise you on CIP and SIP systems \u2013 by phone at <a href=\"tel:+494203789492\">+49 4203 789492<\/a> or by e-mail at <a href=\"mailto:inf&#111;&#64;&#115;-vt.ne&#116;\">&#105;nf&#111;&#64;s-&#118;t.net<\/a>.<\/div><div class=\"svt-pcta-btns\"><a class=\"svt-btn svt-btn-primary\" href=\"\/contact\/?lang=en&amp;produkt=Verfahrenstechnische%20Beratung\">Request a consultation<\/a><a class=\"svt-btn svt-btn-ghost\" href=\"\/process-technology\/?lang=en\">All consulting services<\/a><\/div><\/div><h2>More consulting services<\/h2><div class=\"svt-sgrid\"><a class=\"svt-scard\" href=\"\/homogenisation-technology\/?lang=en\"><span>Homogenisation technology<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/process-engineering\/?lang=en\"><span>Agitation and homogenisation technology<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/temperature-control-systems\/?lang=en\"><span>Temperature control systems<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/transfer-systems\/?lang=en\"><span>Transfer systems<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/control-systems\/?lang=en\"><span>Control systems<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/software-interface-description\/?lang=en\"><span>Software &amp; interface descriptions<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/di-water-plants\/?lang=en\"><span>DI water systems &amp; ring mains<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/steam-plants\/?lang=en\"><span>Steam systems<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/storage-tanks-containers\/?lang=en\"><span>Storage tanks &amp; containers<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><a class=\"svt-scard\" href=\"\/pipelines\/?lang=en\"><span>Pipelines<\/span><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/a><\/div><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Design of CIP and SIP systems\",\"description\":\"Consulting on the design, cleaning procedures and procurement of CIP and SIP systems and hygienic plant design for pharmaceutical and cosmetic production.\",\"url\":\"https:\/\/www.s-vt.net\/cip-sip-systems\/?lang=en\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is the difference between CIP and SIP?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"CIP (Cleaning in Place) cleans vessels, pipelines and valves without dismantling. 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