{"id":4043,"date":"2015-03-26T13:53:56","date_gmt":"2015-03-26T13:53:56","guid":{"rendered":"http:\/\/mirror.s-vt.net\/prozesstechnik-ruehr-homogenisiertechnik\/"},"modified":"2026-10-26T21:43:39","modified_gmt":"2026-10-26T20:43:39","slug":"process-engineering","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/en\/process-engineering\/","title":{"rendered":"Process Engineering in Agitation &#038; Homogenisation"},"content":{"rendered":"<section class='page-content' style=''  ><section class='container'><div class='row' style=''><div class='col-md-12 ' style=''><div class='cma-wysiwyg-editor'><h2><strong>Checklist: 12 points for planning your process plant<\/strong><\/h2><p class=\"svt-lead2\">Many factors interact when designing process plants for agitation and homogenisation technology \u2013 from standards and materials to documentation. The following checklist therefore shows the 12 most important points. Click on a point to see the details.<\/p><details class=\"svt-ck\" open><summary><span class=\"svt-ck-n\">1<\/span><h3 class=\"svt-ck-t\">Which standards must be observed in process engineering?<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>CE conformity<\/li>\n<li>Pressure vessels e.g. PED 97\/23\/EC\/AD2000-HPO, T\u00dcV \u2013 Certificate EN 729\/2, ASME U-Stamp etc.<\/li>\n<li>Power supply \u2013 voltage e.g. \u2013 400 V , 50 Hz<\/li>\n<li>Control voltage e.g. 24 V DC<\/li>\n<li>ATEX approval<\/li>\n<li>Temperature max. Product<\/li>\n<li>Ambient conditions \u2013 temperature \u2013 humidity etc.<\/li>\n<li>Steam pressure<\/li>\n<li>Compressed air pressure<\/li>\n<li>Cooling water \u00b0C<\/li>\n<li>Quantities of cooling water<\/li>\n<li>etc.<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">2<\/span><h3 class=\"svt-ck-t\">Size and performance of the process plant<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>What quantities are to be processed and in what time.<\/li>\n<li>Which products\/product types are to be produced.<\/li>\n<li>Which viscosities are to be processed<\/li>\n<li>Unpressurised operation<\/li>\n<li>Vacuum-tight design<\/li>\n<li>Pressure-resistant design ( e.g. for sterilization)<\/li>\n<li>GAMP \u2013 compliant design \u2013 cGAMP \u2013 EC GMP<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">3<\/span><h3 class=\"svt-ck-t\">Specify choice of materials for product contact areas<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Areas with product contact<\/li>\n<li>Areas without product contact<\/li>\n<li>Scraper materials<\/li>\n<li>Sealing materials\n<ul>\n<li>Properties and durability<\/li>\n<\/ul>\n<\/li>\n<li>Other requirements<\/li>\n<li>Material test attestation \u2013 certificates\n<ul>\n<li>without<\/li>\n<li>Factory certification 2.2<\/li>\n<li>Certificate 3.1 (b)<\/li>\n<li>Certificate 2.2 and 3.1 (b)<\/li>\n<\/ul>\n<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">4<\/span><h3 class=\"svt-ck-t\">Surfaces<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Areas with product contact e.g.\n<ul>\n<li>Ground K 320<\/li>\n<li>Mechanically high-gloss polished Ra 0,6<\/li>\n<li>Electro-polished<\/li>\n<li>Other requirements<\/li>\n<\/ul>\n<\/li>\n<li>Areas without product contact<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">5<\/span><h3 class=\"svt-ck-t\">Machinery<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Scraper material: e.g.\n<ul>\n<li>PTFE<\/li>\n<li>Delrin (POM)<\/li>\n<\/ul>\n<\/li>\n<li>Anchor agitator with scraper agitator\n<ul>\n<li>Agitator seal<\/li>\n<li>Vertical mixing<\/li>\n<li>Left- right rotation<\/li>\n<\/ul>\n<\/li>\n<li>Protective equipment<\/li>\n<li>Hot Cold production \u2013 saving on production times\n<ul>\n<li>Self-priming system<\/li>\n<\/ul>\n<\/li>\n<li>Homogeniser\n<ul>\n<li>Type of sealing<\/li>\n<li>Water-cooled motor<\/li>\n<li>Sealing liquid systems\n<ul>\n<li>monitored<\/li>\n<li>cooled<\/li>\n<li>forced circulation<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>Equipment options for the circulating line according to requirements, such as:\n<ul>\n<li>Nominal width of the circulating line<\/li>\n<li>Flow<\/li>\n<li>Conductivity<\/li>\n<li>Pressure<\/li>\n<li>Ph value<\/li>\n<li>Viscosity<\/li>\n<li>Sampling<\/li>\n<\/ul>\n<\/li>\n<li>Equipment options in the lid area according to requirements:\n<ul>\n<li>Ventilation\n<ul>\n<li>Filter<\/li>\n<li>Sterile air filter<\/li>\n<\/ul>\n<\/li>\n<li>Vacuum \/ pressure \/ nitrogen blanketing<\/li>\n<li>Safety equipment<\/li>\n<li>Automatic pressure and vacuum control<\/li>\n<li>Powder intake\n<ul>\n<li>Hose qualities<\/li>\n<\/ul>\n<\/li>\n<li>Liquid intake\n<ul>\n<li>Hose qualities<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Dosing vessels \/ Active agent vessels<\/li>\n<li>Dosing of different raw materials<\/li>\n<li>Hand-hole openings \/ Manway openings<\/li>\n<li>Sampling<\/li>\n<li>Intake valves for solids and liquids<\/li>\n<li>Automatic dosages<\/li>\n<\/ul>\n<\/li>\n<li>Equipment on the vessel\n<ul>\n<li>Two-zone heating<\/li>\n<li>Hopper scales\n<ul>\n<li>Decoupling the scales<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>CIP \u2013 Cleaning equipment\n<ul>\n<li>Pipes and valves<\/li>\n<li>Stationary cleaning equipment built into cover<\/li>\n<li>Rotating system underneath the cover<\/li>\n<li>Fully-automatic CIP \/ SIP cleaning<\/li>\n<\/ul>\n<\/li>\n<li>Suction device<\/li>\n<li>Cover lock Depending on requirements with\n<ul>\n<li>Safety clamp lock<\/li>\n<li>Locking and venting valve<\/li>\n<li>Or with screwed-on machine covers<\/li>\n<\/ul>\n<\/li>\n<li>Cover lifting device\n<ul>\n<li>Machine bases\n<ul>\n<li>hydraulic<\/li>\n<li>electric<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>Other accessories\/equipment<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">6<\/span><h3 class=\"svt-ck-t\">Measuring devices<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Temperature<\/li>\n<li>Pressure<\/li>\n<li>Flow<\/li>\n<li>Ph value<\/li>\n<li>Conductivity<\/li>\n<li>Particle size measurement<\/li>\n<li>Viscosity measurement<\/li>\n<li>Other measuring devices<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">7<\/span><h3 class=\"svt-ck-t\">Energy<\/h3><\/summary><div class=\"svt-ck-b\"><p>Heating \u2013 cooling controls<\/p>\n<ul>\n<li>Heating direct with steam via control valves<\/li>\n<li>Secondary heating \u2013 hot water circuit heated by steam, via control valves<\/li>\n<li>Secondary heating \u2013 Hot water circuit electrically heated<\/li>\n<li>Temperature measurements \u2013 Product \/ Heating circuit\n<ul>\n<li>Regulation strategies\n<ul>\n<li>Temperature difference regulation \u2013 Delta T regulation<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;Timer-controlled heating and cooling \u2013 Ramp function<\/p><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">8<\/span><h3 class=\"svt-ck-t\">Vacuum control<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Water ring vacuum pumps from 2m\u00b3\/h to 400 m\u00b3\/h<\/li>\n<li>Pressure and vacuum regulation<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">9<\/span><h3 class=\"svt-ck-t\">Wiring<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Cable protection system<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">10<\/span><h3 class=\"svt-ck-t\">Controls<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>Manual<\/li>\n<li>Semi-automatic \u2013 fully automatic process chain procedures\n<ul>\n<li>Process steps can be individually controlled<\/li>\n<\/ul>\n<\/li>\n<li>Control e.g. Siemens S7 \u2013 Rockwell<\/li>\n<li>Visualization systems e.g. \u2013 Siemens Win CC \u2013 Wonderware in Touch HMI<\/li>\n<li>Touch colour display<\/li>\n<li>IPC \u2013 Touch \u2013 colour display, schematically visualized, error analysis<\/li>\n<li>Diagnostic system<\/li>\n<li>Recipe method \u2013\n<ul>\n<li>scaling \u2013 up \u2013 capable system<\/li>\n<\/ul>\n<\/li>\n<li>Recipe management<\/li>\n<li>Batch report<\/li>\n<li>Historical and real-time trends<\/li>\n<li>High degree of automation<\/li>\n<li>Validatable processes<\/li>\n<li>Process control concept with FDA-compliant user management<\/li>\n<li>FDA 21 CFR Part 11 \u2013 compliant electronic process data recording<\/li>\n<\/ul><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">11<\/span><h3 class=\"svt-ck-t\">Quality assurance<\/h3><\/summary><div class=\"svt-ck-b\"><p>Qualification concept<\/p>\n<ul>\n<li>URS \u2013 User requirements<\/li>\n<li>RS&nbsp;\u2013 Requirement specification<\/li>\n<li>RA \u2013 Risk analyses\n<ul>\n<li>DQ Design qualification<\/li>\n<li>IQ Installation qualification<\/li>\n<li>OQ Operational qualification<\/li>\n<li>PQ Product qualification\n<ul>\n<li>including risk analysis<\/li>\n<\/ul>\n<\/li>\n<li>Factory certificates\n<ul>\n<li>Approval certificate 3.1 in accordance with DIN EN 10204<\/li>\n<li>Approval certificate 3.2 in accordance with DIN EN 10204<\/li>\n<li>Factory certificate 2.2 in accordance with EN 10204: 2004<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li>Welding documentation<\/li>\n<\/ul>\n<p>cGMP \/ EG-GMP \/ GAMP- compliant design<\/p><\/div><\/details><details class=\"svt-ck\"><summary><span class=\"svt-ck-n\">12<\/span><h3 class=\"svt-ck-t\">Documentation<\/h3><\/summary><div class=\"svt-ck-b\"><ul>\n<li>CE \u2013 compliant machine documentation<\/li>\n<\/ul><\/div><\/details><h2><strong>Homogenising mixers in detail<\/strong><\/h2><figure class=\"svt-fig\"><img decoding=\"async\" src=\"https:\/\/www.s-vt.net\/wp-content\/uploads\/2017\/01\/homogenisiermischer-prozessanlage-1024x608.jpg\" alt=\"Process plant for agitation and homogenisation technology with homogenising mixer\" width=\"1024\" height=\"608\" loading=\"lazy\" \/><figcaption>Process plant for agitation and homogenisation technology with homogenising mixer<\/figcaption><\/figure><p>For a plant in agitation and homogenisation technology to work reliably, the homogenising mixer should also offer the following features:<\/p><div class=\"svt-kgrid svt-kgrid-2\"><div class=\"svt-kcard\"><h3>Details of homogenization technology of mixers<\/h3><p>Depending on the product, attention is to be paid to the following<\/p>\n<ul class=\"svt-klist\">\n<li>Highly efficient agitator and homogenization system in all speed ranges<\/li>\n<li>Fast and easy-to-operate cover with safety locking device<\/li>\n<li>Radial and vertical mixing of liquid and semi-solid products<\/li>\n<li>Homogenization of small quantities in the vessel<\/li>\n<li>Procedure for comfortable suction, as well as dispersion of powders<\/li>\n<li>Homogenization internally in the vessel, as well as in the circuit<\/li>\n<li>Automatic raising and lowering of the cover and agitator in the case of smaller machine units<\/li>\n<li>Pressure and vacuum proof machine design (CIP \u2013 SIP \u2013 design)<\/li>\n<li>Clean and easy attachment of the scraper systems<\/li>\n<li>Suction of water and fatty phases using the hot-cold process<\/li>\n<li>Control of the heating and cooling processes using different regulation strategies<\/li>\n<\/ul>\n<p>Depending on requirements, simple touch operation up to fully-automatic recipe and batch control, with GMP \u2013 compliant documentation in the case of pharmaceutical applications<\/p><\/div><div class=\"svt-kcard\"><h3>The homogenization mixer should provide the following application options<\/h3><ul class=\"svt-klist\">\n<li><a href=\"\/agitation\/?lang=en\">Agitating<\/a><\/li>\n<li><a href=\"\/emulsification\/?lang=en\">Emulsifying<\/a><\/li>\n<li><a href=\"\/mixing\/?lang=en\">Mixing<\/a><\/li>\n<li>Venting<\/li>\n<li><a href=\"\/dispersion\/?lang=en\">Dispersing<\/a><\/li>\n<li><a href=\"\/deaeration\/?lang=en\">Degassing<\/a><\/li>\n<li><a href=\"\/suspension\/?lang=en\">Suspending<\/a><\/li>\n<li><a href=\"\/homogenisation\/?lang=en\">Homogenizing<\/a><\/li>\n<li><a href=\"\/agglomeration\/?lang=en\">Agglomeration<\/a><\/li>\n<li>Evacuation<\/li>\n<\/ul>\n<p>Sterile production (depending on requirements)<\/p><\/div><div class=\"svt-kcard\"><h3>Important for the choice of homogenizing mixer<\/h3><p>High quality homogenizing mixers, their performance and flexibility can significantly reduce production times and costs. The special efficiency of such agitators is due to a variety of factors: It should, therefore, be ensured that the rotor-stator-system is protected against extraneous parts. The infinitely variable speed adjustment and the design of the agitator, as well as that of the homogenizer, should allow highly efficient <a href=\"\/agitation\/?lang=en\">agitation<\/a>and&nbsp;<a href=\"\/homogenisation\/?lang=en\">homogenization<\/a>.<\/p><p>Also on this point, care should be taken that the design is GMP-compliant. Intensive&nbsp;<a href=\"\/homogenisation\/?lang=en\">homogenization&nbsp;<\/a>in the vessel as well as in the circulation procedure and <a href=\"\/homogenisation\/?lang=en\">homogenization&nbsp;<\/a>of small quantities should be possible in the agitator. A particularly high value should be placed on clean scraping in the rotation direction change operation.<\/p><p>The efficient suction of powder and the&nbsp;<a href=\"\/dispersion\/?lang=en\">dispersion&nbsp;<\/a>into liquids and semi-solids should be possible without great dust emission in the vessel. According to requirements, a pressure and vacuum-tight design should be considered, in order to ensure consistent qualities.&nbsp;<strong><a href=\"\/cip-sip-systems\/?lang=en\">The&nbsp;<\/a><strong>SIP and aseptic GMP design, as well as the integrated CIP design<\/strong>&nbsp;<\/strong>should be suitable for compliance with all hygiene regulations.<\/p><\/div><div class=\"svt-kcard\"><h3>Advantages of product manufacture with multi-vessel process plants<\/h3><p>The combination of several processing units in a complete process plant has a number of advantages. In this way individual production phases can already be produced in parallel and subsequently combined into a process. This saves time for production and the cleaning of the plants.<\/p>\n<ul class=\"svt-klist\">\n<li>Separate vessel for different phases<\/li>\n<li>Transfer connections to combine raw products and parts of the finished product.<\/li>\n<li>Special&nbsp;<a href=\"\/cip-sip-systems\/?lang=en\">CIP and SIP cleaning (cleaning-in-place and sterilizing-in-place)<\/a>&nbsp;can be integrated into every process unit<\/li>\n<li>Parallel use of several vessels and\/or agitators offer great possibilities for batch time reduction<\/li>\n<li>High machine quality increases end product quality<\/li>\n<li>High flexibility allows for more versatility in the production<\/li>\n<\/ul><\/div><div class=\"svt-kcard\"><h3>Efficiency, Flexibility, Quality<\/h3><p>For the different phases of a product, individual production components are to be integrated which contribute to the economic efficiency of your production. All plant components should be so installed that production can be carried out independently within sections of the plant. For you, this means optimal time utilization during the production process, as all components can be operated in parallel. Depending on requirements, all components should be equipped with <a href=\"\/cip-sip-systems\/?lang=en\">CIP and SIP cleaning devices<\/a>.&nbsp;All plant parts can, if required, be equipped with measuring, dosing and pumping technology. The&nbsp;<a href=\"\/transfer-systems\/?lang=en\"><strong>transfer<\/strong><\/a>&nbsp;of the raw material from the&nbsp;<a href=\"\/storage-tanks-containers\/?lang=en\">storage tanks<\/a>&nbsp;into the plant takes place by means of vacuum or with corresponding <strong><a href=\"\/transfer-systems\/?lang=en\">transfer pumps<\/a>.<\/strong><strong>&nbsp;<\/strong><strong>SEEFRIED Verfahrenstechnik GmbH<\/strong>&nbsp;can offer you technical solutions, also for the expansion or conversion of already existing plants.<\/p><\/div><div class=\"svt-kcard\"><h3>CIP \u2013 Cleaning device<\/h3><ul class=\"svt-klist\">\n<li>Mounted into lid<\/li>\n<li>Rotating system underneath the lid<\/li>\n<li>Steam melting of fatty components before the cleaning process<\/li>\n<\/ul><\/div><\/div><h2><strong>Equipment options<\/strong><\/h2><div class=\"svt-kgrid svt-kgrid-3\"><div class=\"svt-kcard\"><h3>Combinable phase vessel<\/h3><ul class=\"svt-klist\">\n<li>Pre-phase vessel for fat and water phases<\/li>\n<li>Raw materials supply for automated filling with raw materials (liquid and solid)<\/li>\n<li>A variety of measurement units, for example\n<ul>\n<li>pH probes<\/li>\n<li>Conductivity<\/li>\n<li>Pressure<\/li>\n<li>Temperature<\/li>\n<li>Viscosity meter<\/li>\n<li>Flow rate meter etc.<\/li>\n<\/ul>\n<\/li>\n<\/ul><\/div><div class=\"svt-kcard\"><h3>Vessel materials<\/h3><p>The parts of the plant in contact with the product should be made of durable stainless steel and meet the product requirements.&nbsp;<\/p><\/div><div class=\"svt-kcard\"><h3>Heating and cooling control<\/h3><ul class=\"svt-klist\">\n<li>Direct and indirect heating systems<\/li>\n<li>Direct heating with steam via double casing<\/li>\n<li>Zone heating with ramp control optionally combinable, through to fully-automated heating system<\/li>\n<li>Steam and hot water direct or via a secondary circuit with heat exchangers<\/li>\n<\/ul><\/div><div class=\"svt-kcard\"><h3>Vacuum control<\/h3><p>Vacuum pump automatically creates a vacuum and regulates the pressure in the vessel.<\/p><\/div><div class=\"svt-kcard\"><h3>Controls and operation<\/h3><p>PLC control by means of a small touch-panel or complete visualization via PC, with recording and recipe procedure according to customer requirements.<\/p><\/div><\/div><p class=\"svt-knote\"><strong>SEEFRIED Verfahrenstechnik GmbH can support you in the selection and <\/strong>procurement of the optimal process technology for your products.&nbsp;<\/p><h2><strong>Frequently Asked Questions about designing agitation and homogenization plants<\/strong><\/h2><h3>What matters when designing a homogenizing mixer?<\/h3><p>Key factors are the applicable standards (e.g. CE, Pressure Equipment Directive, ATEX), size and capacity of the plant, materials and surfaces of product-contact areas, machine equipment, measuring, heating, cooling and vacuum technology, the control system, as well as qualification and documentation.<\/p><h3>What are the advantages of multi-vessel process plants?<\/h3><p>Individual product phases can be prepared in parallel and then combined. This saves time in production and cleaning. CIP and SIP cleaning can be integrated into every process unit, and the plant remains flexible.<\/p><h3>Which control and documentation requirements can pharma-compliant plants meet?<\/h3><p>Options include Siemens S7 or Rockwell controls with visualization, recipe management, batch reports and FDA 21 CFR Part 11 compliant process data recording, as well as qualification (DQ, IQ, OQ, PQ) and material certificates according to DIN EN 10204.<\/p><h3>Do you also support the expansion of existing plants?<\/h3><p>Yes. We offer technical solutions for the expansion or conversion of existing plants and support you in selecting and procuring the right process technology.<\/p><p><h2 class=\"svt-pcta-h\">Planning a new process plant or expanding an existing one?<\/h2><div class=\"svt-pcta svt-pcta-m\"><div class=\"svt-pcta-tx\">We support you with design, selection and procurement of your agitation and homogenisation technology \u2013 by phone at <a href=\"tel:+494203789492\">+49 4203 789492<\/a> or by e-mail at <a href=\"mailto:i&#110;&#102;o&#64;&#115;-&#118;t&#46;&#110;et\">in&#102;&#111;&#64;&#115;&#45;vt.&#110;e&#116;<\/a>.<\/div><div class=\"svt-pcta-btns\"><a class=\"svt-btn svt-btn-primary\" href=\"\/contact\/?lang=en&amp;produkt=Verfahrenstechnische%20Beratung\">Request a consultation<\/a><a class=\"svt-btn svt-btn-ghost\" href=\"\/used-homogenising-mixers-process-plants\/?lang=en\">Used homogenising mixers<\/a><\/div><\/div><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Design of agitation and homogenization plants\",\"description\":\"Consulting on the design, equipment, control and qualification of homogenizing mixers and multi-vessel process plants for pharmaceutical and cosmetic production.\",\"url\":\"https:\/\/www.s-vt.net\/process-engineering\/?lang=en\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What matters when designing a homogenizing mixer?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Key factors are the applicable standards (e.g.<\/p><p>CE, Pressure Equipment Directive, ATEX), size and capacity of the plant, materials and surfaces of product-contact areas, machine equipment, measuring, heating, cooling and vacuum technology, the control system, as well as qualification and documentation.\"}},{\"@type\":\"Question\",\"name\":\"What are the advantages of multi-vessel process plants?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Individual product phases can be prepared in parallel and then combined. This saves time in production and cleaning.<\/p><p>CIP and SIP cleaning can be integrated into every process unit, and the plant remains flexible.\"}},{\"@type\":\"Question\",\"name\":\"Which control and documentation requirements can pharma-compliant plants meet?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Options include Siemens S7 or Rockwell controls with visualization, recipe management, batch reports and FDA 21 CFR Part 11 compliant process data recording, as well as qualification (DQ, IQ, OQ, PQ) and material certificates according to DIN EN 10204.\"}},{\"@type\":\"Question\",\"name\":\"Do you also support the expansion of existing plants?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes.<\/p><p>We offer technical solutions for the expansion or conversion of existing plants and support you in selecting and procuring the right process technology.\"}}]}]}<\/script><\/p><\/div><\/div><\/div><\/section><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"class_list":["post-4043","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Agitation and Homogenisation Technology: Plant Design | SEEFRIED<\/title>\n<meta name=\"description\" content=\"Checklist for designing homogenizing mixers and process plants: standards, materials, surfaces, equipment, controls, qualification and documentation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.s-vt.net\/en\/process-engineering\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Agitation and Homogenisation Technology: Plant Design | SEEFRIED\" \/>\n<meta property=\"og:description\" content=\"Checklist for designing homogenizing mixers and process plants: standards, materials, surfaces, equipment, controls, qualification and documentation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.s-vt.net\/en\/process-engineering\/\" \/>\n<meta property=\"og:site_name\" content=\"SEEFRIED Verfahrenstechnik GmbH\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-26T20:43:39+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/en\\\/process-engineering\\\/\",\"url\":\"https:\\\/\\\/www.s-vt.net\\\/en\\\/process-engineering\\\/\",\"name\":\"Agitation and Homogenisation Technology: Plant Design | SEEFRIED\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/#website\"},\"datePublished\":\"2015-03-26T13:53:56+00:00\",\"dateModified\":\"2026-10-26T20:43:39+00:00\",\"description\":\"Checklist for designing homogenizing mixers and process plants: standards, materials, surfaces, equipment, controls, qualification and documentation.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/en\\\/process-engineering\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.s-vt.net\\\/en\\\/process-engineering\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.s-vt.net\\\/en\\\/process-engineering\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/www.s-vt.net\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Process Engineering in Agitation &#038; 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