{"id":11057,"date":"2026-11-03T11:25:42","date_gmt":"2026-11-03T10:25:42","guid":{"rendered":"https:\/\/www.s-vt.net\/?page_id=11057"},"modified":"2026-11-03T11:25:42","modified_gmt":"2026-11-03T10:25:42","slug":"nasal-drops","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/pt\/nasal-drops\/","title":{"rendered":"Gotas nasais"},"content":{"rendered":"<div style='' class=''><section class='page-content' style=''  ><section class='container'><div style='' class=''><div class='row' style=''><div style='' class=''><div class='col-md-12 ' style=''><div style='' class=''><div class='cma-wysiwyg-editor'><p class=\"svt-lead2\">A produ\u00e7\u00e3o de gotas nasais exige conhecimentos cient\u00edficos e processos de produ\u00e7\u00e3o precisos. As gotas nasais diferem de muitos outros <a href=\"\/pt\/pharmaceuticals\/\">produtos farmac\u00eauticos<\/a> por serem subst\u00e2ncias aquosas que s\u00e3o misturadas com outras fases.<\/p><div class=\"svt-ptiles\"><div class=\"svt-ptile\"><i class=\"fa fa-expand\" aria-hidden=\"true\"><\/i><strong>Scale-up preciso<\/strong><span>Design id\u00eantico, do laborat\u00f3rio \u00e0 instala\u00e7\u00e3o de processo.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-shield\" aria-hidden=\"true\"><\/i><strong>Est\u00e9ril e GMP<\/strong><span>V\u00e1lvulas ass\u00e9pticas e design CIP integrado.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-database\" aria-hidden=\"true\"><\/i><strong>Documenta\u00e7\u00e3o completa<\/strong><span>Gest\u00e3o de receitas com documenta\u00e7\u00e3o cont\u00ednua de todas as etapas.<\/span><\/div><\/div><h2>Requisitos espec\u00edficos da produ\u00e7\u00e3o<\/h2><p>As gotas nasais exigem ciclos de produ\u00e7\u00e3o espec\u00edficos. Al\u00e9m disso, na produ\u00e7\u00e3o farmac\u00eautica aplicam-se crit\u00e9rios de seguran\u00e7a e qualidade extremamente rigorosos, e os ensaios de qualidade ocupam a maior parte do tempo de produ\u00e7\u00e3o. A natureza espec\u00edfica dos componentes dificulta ainda mais a produ\u00e7\u00e3o.<\/p><h2>Requisitos da instala\u00e7\u00e3o de agita\u00e7\u00e3o e homogeneiza\u00e7\u00e3o<\/h2><p>Para que a produ\u00e7\u00e3o decorra com exatid\u00e3o e sem desvios de qualidade, a instala\u00e7\u00e3o tem de cumprir todos os requisitos relevantes para a produ\u00e7\u00e3o:<\/p><ul class=\"svt-checks\"><li>design e dimensionamento de pot\u00eancia id\u00eanticos para um scale-up preciso da escala laboratorial at\u00e9 \u00e0 instala\u00e7\u00e3o de processo<\/li><li>qualidade do produto constantemente elevada com uma condu\u00e7\u00e3o do processo r\u00e1pida e precisa<\/li><li>v\u00e1lvulas ass\u00e9pticas e design conforme \u00e0s GMP<\/li><li>integra\u00e7\u00e3o de <a href=\"\/cip-sip-systeme\/\">Cleaning-in-Place (CIP)<\/a> para produ\u00e7\u00e3o est\u00e9ril e higiene<\/li><\/ul><h2>Sistema de comando e documenta\u00e7\u00e3o<\/h2><p>Tamb\u00e9m \u00e9 de grande import\u00e2ncia a documenta\u00e7\u00e3o exata de todas as etapas de produ\u00e7\u00e3o. As solu\u00e7\u00f5es v\u00e3o desde um pequeno sistema de comando por receitas com gravador de dados separado at\u00e9 uma visualiza\u00e7\u00e3o completa em painel t\u00e1til.<\/p><p>As solu\u00e7\u00f5es de maior dimens\u00e3o incluem uma sequ\u00eancia de receitas integrada para as etapas de produ\u00e7\u00e3o e de limpeza, uma documenta\u00e7\u00e3o cont\u00ednua em segundo plano e a opera\u00e7\u00e3o atrav\u00e9s de um <a href=\"\/steuerungen\/\">sistema de comando central<\/a>. Assim, cada cliente obt\u00e9m o programa adequado.<\/p><h2>FAQ: produ\u00e7\u00e3o de gotas nasais<\/h2><h3>Como s\u00e3o produzidas as gotas nasais?<\/h3><p>Os princ\u00edpios ativos s\u00e3o dissolvidos numa base aquosa, adicionam-se tamp\u00f5es, agentes de isotoniza\u00e7\u00e3o e, se necess\u00e1rio, conservantes, ajusta-se o pH, filtra-se e envasa-se com baixa carga microbiana ou em condi\u00e7\u00f5es est\u00e9reis.<\/p><h3>Que requisitos se aplicam \u00e0 instala\u00e7\u00e3o de processo?<\/h3><p>V\u00e1lvulas ass\u00e9pticas, design GMP, limpeza CIP sem zonas mortas, aptid\u00e3o para SIP e instrumenta\u00e7\u00e3o precisa de medi\u00e7\u00e3o e regula\u00e7\u00e3o para pH e temperatura.<\/p><h3>Como se realiza o scale-up?<\/h3><p>Atrav\u00e9s de instala\u00e7\u00f5es de laborat\u00f3rio e de produ\u00e7\u00e3o com constru\u00e7\u00e3o e dimensionamento de pot\u00eancia id\u00eanticos. Assim, a qualidade do produto mant\u00e9m-se igual do ensaio \u00e0 produ\u00e7\u00e3o.<\/p><h3>Por que raz\u00e3o \u00e9 a documenta\u00e7\u00e3o t\u00e3o importante?<\/h3><p>Para a aprova\u00e7\u00e3o de lotes conforme \u00e0s GMP, todas as etapas de produ\u00e7\u00e3o e limpeza s\u00e3o documentadas automaticamente, desde o simples sistema de comando por receitas at\u00e9 ao sistema de comando do processo (DCS).<\/p><h3>A SEEFRIED presta apoio em instala\u00e7\u00f5es para gotas nasais?<\/h3><p>Sim, com planifica\u00e7\u00e3o, qualifica\u00e7\u00e3o e instala\u00e7\u00f5es de agita\u00e7\u00e3o e homogeneiza\u00e7\u00e3o adequadas para produtos farmac\u00eauticos l\u00edquidos.<\/p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Instala\u00e7\u00f5es de processo para a produ\u00e7\u00e3o de gotas nasais\",\"description\":\"Planifica\u00e7\u00e3o, qualifica\u00e7\u00e3o e fornecimento de instala\u00e7\u00f5es de agita\u00e7\u00e3o e homogeneiza\u00e7\u00e3o conformes \u00e0s GMP para gotas nasais e sprays nasais.\",\"url\":\"https:\/\/www.s-vt.net\/pt\/nasal-drops\/\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Como s\u00e3o produzidas as gotas nasais?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Os princ\u00edpios ativos s\u00e3o dissolvidos numa base aquosa, adicionam-se tamp\u00f5es, agentes de isotoniza\u00e7\u00e3o e, se necess\u00e1rio, conservantes, ajusta-se o pH, filtra-se e envasa-se com baixa carga microbiana ou em condi\u00e7\u00f5es est\u00e9reis.\"}},{\"@type\":\"Question\",\"name\":\"Que requisitos se aplicam \u00e0 instala\u00e7\u00e3o de processo?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"V\u00e1lvulas ass\u00e9pticas, design GMP, limpeza CIP sem zonas mortas, aptid\u00e3o para SIP e instrumenta\u00e7\u00e3o precisa de medi\u00e7\u00e3o e regula\u00e7\u00e3o para pH e temperatura.\"}},{\"@type\":\"Question\",\"name\":\"Como se realiza o scale-up?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Atrav\u00e9s de instala\u00e7\u00f5es de laborat\u00f3rio e de produ\u00e7\u00e3o com constru\u00e7\u00e3o e dimensionamento de pot\u00eancia id\u00eanticos. 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