{"id":15737,"date":"2026-11-05T18:05:57","date_gmt":"2026-11-05T17:05:57","guid":{"rendered":"https:\/\/www.s-vt.net\/?page_id=15737"},"modified":"2026-11-05T18:05:57","modified_gmt":"2026-11-05T17:05:57","slug":"api-deagglomeration","status":"publish","type":"page","link":"https:\/\/www.s-vt.net\/ro\/api-deagglomeration\/","title":{"rendered":"Dezaglomerarea substan\u021belor active"},"content":{"rendered":"<div style='' class=''><section class='page-content' style=''  ><section class='container'><div style='' class=''><div class='row' style=''><div style='' class=''><div class='col-md-12 ' style=''><div style='' class=''><div class='cma-wysiwyg-editor'><p class=\"svt-lead2\">La fabricarea produselor farmaceutice se formeaz\u0103 adesea, \u00een etapele preliminare, <a href=\"\/ro\/agglomeration\/\">particule aglomerate<\/a> \u2013 mai ales la amestecurile de pulberi \u0219i lichide. Pentru procesul ulterior, aceste aglomer\u0103ri trebuie dizolvate, iar materiile prime m\u0103run\u021bite; acest proces se nume\u0219te dezaglomerarea substan\u021belor active.<\/p><div class=\"svt-ptiles\"><div class=\"svt-ptile\"><i class=\"fa fa-cogs\" aria-hidden=\"true\"><\/i><strong>Sistem rotor-stator<\/strong><span>M\u0103run\u021bire optim\u0103 a solidelor \u00een lichid.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-clock-o\" aria-hidden=\"true\"><\/i><strong>\u00cen c\u00e2teva minute<\/strong><span>Solu\u021bii f\u0103r\u0103 aglomerate \u00een timp scurt.<\/span><\/div><div class=\"svt-ptile\"><i class=\"fa fa-bullseye\" aria-hidden=\"true\"><\/i><strong>Precizie mai mare a doz\u0103rii<\/strong><span>Suspensii mai omogene \u0219i substan\u021be active dizolvate mai rapid.<\/span><\/div><\/div><h2>De ce nu este suficient un agitator singur<\/h2><p>Un agitator conven\u021bional nu poate dizolva fiabil aglomeratele. Instala\u021biile de proces moderne cu sisteme integrate, performante, de agitare \u0219i <a href=\"\/ro\/homogenizing\/\">omogenizare<\/a> sunt, \u00een schimb, ideale pentru aceasta.<\/p><p>Sistemul lor rotor-stator m\u0103run\u021be\u0219te optim solidele \u0219i m\u0103re\u0219te totodat\u0103 suprafa\u021ba pulberii \u00een lichid. Astfel rezult\u0103 \u00een c\u00e2teva minute solu\u021bii f\u0103r\u0103 aglomerate.<\/p><h2>Avantajele dezaglomer\u0103rii substan\u021belor active<\/h2><p>Prin dezintegrarea aglomeratelor, \u00eentreaga suprafa\u021b\u0103 a particulelor devine accesibil\u0103 lichidului. Aceasta aduce mai multe avantaje:<\/p><ul class=\"svt-checks\"><li>substan\u021bele active se dizolv\u0103 mai rapid \u0219i mai uniform<\/li><li><a href=\"\/ro\/suspensions\/\">suspensiile<\/a> devin mai omogene<\/li><li>precizia doz\u0103rii cre\u0219te<\/li><li>la substan\u021bele active greu solubile, o dimensiune mai fin\u0103 a particulelor poate \u00eembun\u0103t\u0103\u021bi viteza de dizolvare \u0219i, implicit, biodisponibilitatea<\/li><\/ul><p class=\"svt-knote\">Pentru o micronizare real\u0103, la c\u00e2\u021biva micrometri, se utilizeaz\u0103 de obicei mori cu jet, mori cu perle sau omogenizatoare de \u00eenalt\u0103 presiune. Omogenizatorul rotor-stator preia \u00een special dezaglomerarea, umectarea \u0219i <a href=\"\/ro\/dispersing\/\">dispersarea<\/a>.<\/p><h2>\u00centreb\u0103ri frecvente: dezaglomerarea substan\u021belor active<\/h2><h3>Ce se \u00een\u021belege prin dezaglomerarea substan\u021belor active?<\/h3><p>Dizolvarea aglomeratelor \u0219i a cocoloa\u0219elor care se formeaz\u0103 la amestecarea substan\u021belor active pulverulente cu lichide. Scopul este o distribu\u021bie fin\u0103 \u0219i uniform\u0103 a fiec\u0103rei particule \u00een parte.<\/p><h3>De ce nu este suficient un agitator obi\u0219nuit?<\/h3><p>Un agitator genereaz\u0103 for\u021be de forfecare reduse. Aglomeratele se p\u0103streaz\u0103, apar cuiburi de pulbere. Abia forfecarea ridicat\u0103 din fanta rotor-stator a unui omogenizator le dezintegreaz\u0103 fiabil.<\/p><h3>Ce avantaje aduce o dezaglomerare bun\u0103?<\/h3><p>Timpi mai scur\u021bi de dizolvare \u0219i de proces, distribu\u021bie omogen\u0103 a substan\u021bei active, precizie mai mare a doz\u0103rii \u0219i o suprafa\u021b\u0103 activ\u0103 mai mare a particulelor, ceea ce poate \u00eembun\u0103t\u0103\u021bi viteza de dizolvare \u0219i biodisponibilitatea.<\/p><h3>Cum se \u00eencorporeaz\u0103 optim pulberile?<\/h3><p>Prin aspirare de pulbere sub vid, direct \u00een zona de forfecare a omogenizatorului, sub nivelul lichidului, astfel \u00eenc\u00e2t fiecare particul\u0103 s\u0103 fie umectat\u0103 imediat.<\/p><h3>Ofer\u0103 SEEFRIED solu\u021bii pentru dezaglomerare?<\/h3><p>Da, prin consultan\u021b\u0103 \u00een ingineria proceselor, planificarea \u00eencerc\u0103rilor \u0219i mixere-omogenizatoare adecvate, inclusiv second-hand.<\/p><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Service\",\"name\":\"Dezaglomerarea substan\u021belor active cu mixere-omogenizatoare\",\"description\":\"Consultan\u021b\u0103 de proces \u0219i mixere-omogenizatoare pentru dezaglomerarea fiabil\u0103 a substan\u021belor active pulverulente \u00een lichide.\",\"url\":\"https:\/\/www.s-vt.net\/ro\/api-deagglomeration\/\",\"provider\":{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.s-vt.net\/#seefried\",\"name\":\"SEEFRIED Verfahrenstechnik GmbH\",\"url\":\"https:\/\/www.s-vt.net\/\",\"telephone\":\"+49 4203 789492\"},\"areaServed\":\"Worldwide\"},{\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Ce se \u00een\u021belege prin dezaglomerarea substan\u021belor active?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Dizolvarea aglomeratelor \u0219i a cocoloa\u0219elor care se formeaz\u0103 la amestecarea substan\u021belor active pulverulente cu lichide. 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