In the production of pharmaceutical pastes, base substances and active ingredients are combined into a stable, durable and effective finished preparation. These pastes are intended for external use.
Effect and composition
Many pharmaceutical pastes dry out wounds and have a secretion-binding and antiseptic effect. For this purpose, active ingredients and other components with different consistencies are combined.
At the start, the components are often in powder form. During production, they must be dispersed or dissolved so that a finely distributed dispersion is formed with the other ingredients. Depending on the product, the solids content is between 25 % and 50 %.
Requirements for the production plant
In addition to hygienic production, handling substances with different viscosities is crucial. Modern plants can be used flexibly and efficiently for this purpose:
- homogenisation in the vessel or in the recirculation process
- variable speed for efficient yet gentle processing
- powder induction under vacuum for a high solids content
- hygienic, GMP-compliant design with CIP cleaning
FAQ: Producing pharmaceutical pastes
What distinguishes pastes from ointments?
Pastes are semi-solid preparations with a high solids content (typically 25 to 50 %), e.g. zinc oxide. They adhere well, dry wounds and bind secretions.
How are high powder loads incorporated?
Powders are drawn in step by step under vacuum and dispersed with a rotor-stator homogeniser until a fine, agglomerate-free distribution is achieved.
Which machine is suitable for pastes?
Vacuum homogenising mixers with a powerful scraper agitator, homogeniser in the vessel or recirculation loop and variable speed for high-viscosity products.
How is air entrapment avoided?
By processing and deaerating under vacuum and using low speeds during powder induction.
Does SEEFRIED supply plants for pastes?
Yes, SEEFRIED Verfahrenstechnik plans plants for semi-solid dosage forms and offers inspected used vacuum homogenising mixers.