Symex CML50

Symex CML50 Homogenizing Mixer SOLD

High-quality Symex CML50 vacuum mixing and homogenizing mixer, designed for demanding applications in the pharmaceutical, cosmetics, and food industries.

The Symex CML50 is a compact, fully integrated process unit for mixing, dispersing, homogenizing, heating, cooling, and evacuating. It is particularly suitable for emulsions, suspensions, gels, and liquid products with high requirements for process reliability, cleanability, and reproducibility.

Symex CML50 – Condition & Availability

✔ This machine has already been sold. Currently available: Symex CML125, Symex P1000 and more used homogenizer mixers.

✔ High-quality industrial unit in pharmaceutical design
✔ Pressure and vacuum resistant vessel
✔ Designed according to PED / AD2000
✔ Documentation, calibration, and test certificates available
✔ Suitable for validatable processes in regulated environments

📍 Location: Weyhe near Bremen

Why buy a Symex CML50?

The Symex CML50 is a compact homogenizing mixer with full process functionality. The system combines vacuum technology, heating/cooling control, agitator, homogenizer, suction, and CIP in a single unit.

… Your advantages at a glance:

✔ Fully-fledged vacuum homogenizing mixer
✔ Suitable for emulsions, suspensions, and gels
✔ Precise process control for small and medium batches
✔ Direct powder and liquid aspiration possible
✔ CIP-compatible, hygienic design
✔ Excellent scale-up and development conditions

Typical applications of the Symex CML50

The Symex CML50 is particularly suitable for:

• Cosmetic creams and lotions
• Pharmaceutical liquids
• Gels and suspensions
• O/W and W/O emulsions
• Development, pilot, and small-batch processes

among other things, liquid/liquid mixing, solid/liquid mixing, heating, cooling, evacuation, pressure control, container-to-container transfer, and hot water cleaning as intended processes.

Technical Highlights of the Symex CML50

• Vacuum and pressure-resistant mixing vessel
• Comb paddle agitator with PTFE scrapers
• Homogenizer in the vessel base
• Long and short circulation for different process requirements
• Direct powder and liquid intake near the homogenizing tool
• CIP system with rotating cleaning nozzles
• Electric heating via secondary circuit
• Direct water cooling
• Integrated vacuum pump
• PLC control with touchscreen operation

Vessel

• Usable volume: approx. 50 liters
• Minimum volume: approx. 12 liters
• Total volume: approx. 90 liters
• Double jacket volume: approx. 8 liters
• Product chamber pressure range: -1 / +2 bar
• Permissible product temperature: up to 133 °C
• Heating/cooling chamber: 0 / +4 bar, up to 151 °C

Materials and surfaces

• Product-contact surfaces: Stainless steel 1.4404 / 316L
• Heating/cooling jacket: 1.4541 / 321
• Frame and control cabinet: Stainless steel
• Product-contact seals: Viton (FKM), FDA compliant
• Inside the container in the wiper area: Ra < 0.4 µm
• Inside the lid: Ra < 0.4 µm
• Mixing tool: Mechanically polished, Ra < 0.4 µm

Agitator

The Symex CML50 is equipped with a Comb-blade agitator system equipped with scrapers and two flow breakers. The system is designed for highly viscous products and supports short mixing times while maintaining good cleanability.

• Mixing medium: Emulsions, suspensions, gels
• Viscosity: up to approx. 100,000 mPas
• Speed: 13 to 111 rpm
• Rated power: 4.25 kW at 87 Hz
• Reversible operation with timer
• Water-cooled motor
• IP54 rated

Homogenizer

A key feature of the Symex CML50 is the Symex Co-Twister HFDC 100. The system operates on the rotor/rotor principle and allows for highly flexible adjustment of pumping and shearing action.

• Pump rotor: 12 kW
• Shear rotor: 9.8 kW
• Rotor speed: up to 9360 rpm
• Shear speed: up to 60 m/s
• Independent control of rotor and shear rotor
• Operation with high shear or in gentle pumping mode possible
• Suitable for sensitive emulsions
• Improved CIP efficiency due to high pumping capacity

Recirculation systems

The Symex CML50 features:

• Long DN40 circulation for pumping, CIP, and emptying
• Short DN20 circulation for small quantities and bottom-level product return

The short circulation is particularly advantageous for small batches, as it actively reduces clouding.

Powder and Liquid Suction

The system features integrated raw material suction technology:

• Pneumatically actuated DN20 suction flap for powders and liquids
• Suction directly in front of the homogenizing tool
• Additional stator direct suction for liquids into the shear gap
• Particularly suitable for gel production and hot/cold processes with O/W emulsions

CIP System

The Symex CML50 is designed for hygienic cleaning:

• Two CIP ports with integrated jet nozzles
• Rotating cleaning nozzles
• Additional washing balls in multi-port ports and handhole
• CIP connection to the circulation line
• Excellent rinsing and cleaning of product-contacting valves and flaps
• Heating, Cooling, and Vacuum

The CML50 features integrated temperature control and vacuum technology:

• Electric heating via secondary circuit
• Three 4 kW electric heating elements
• 1.5 Nm heating circulation pump kW
• Direct water cooling
• Vacuum pump as a liquid ring pump
• Suction flow rate: approx. 38 m³/h at 100 mbar
• Minimum achievable suction pressure: approx. 33 mbar at 25 °C
• operating water temperature

Control and automation

• Siemens S7/300 PLC control
• Color touchscreen PC for operation
• Control of agitator, homogenizer, temperature, and pressure
• Integrated pressure, temperature, and speed measurement
• Measurement signals as 4–20 mA or Pt100
• Control cabinet system with emergency stop and power section in the technical room

Standards, documentation, and qualification

The documentation includes, among other things:

• Machinery Directive 98/37/EC
• Pressure Equipment Directive 97/23/EC
• Vessel design according to PED / AD2000
• Declarations of conformity
• Electrical circuit diagrams
• Vessel test documents
• Calibration documents
• FAT documentation
• Evidence of product-contact materials and certificates

Delivery & Handling

• Ex-Works delivery
• Turnkey projects available (including commissioning)
• 12-month warranty (excluding wear parts)
• International shipping available

Looking for a similar machine?

We can help you source a comparable machine – contact us now for a free, no-obligation enquiry:

📧 info@s-vt.net
Please provide your complete company details.

Currently available alternatives to the Symex CML50

The Symex CML50 has been sold. The following used machines are available at short notice and can be inspected in Weyhe near Bremen, Germany:

• Symex CML125 – vacuum homogenizing mixer, 125 L, pharma design, factory overhauled
• Becomix RW320 – homogenizing mixer, approx. 100–320 L, GMP, CIP/SIP

See all offers in our overview of used homogenizing mixers & process equipment.

Frequently Asked Questions about the Symex CML50

Is the Symex CML50 still available?

No, this machine has already been sold. The technical data on this page is provided for reference, e.g. when looking for a comparable machine.

What were the key specifications of the Symex CML50?

Working volume approx. 50 L (min. approx. 12 L), product chamber -1/+2 bar, up to 133 °C, stainless steel 316L (Ra < 0.4 µm), scraper agitator (13–111 rpm) and homogenizer, pharma design.

What alternatives to the Symex CML50 are available?

Currently available are, among others, Symex CML125, Becomix RW320. We are happy to advise which machine suits your product, batch size and GMP requirements.

Can you source a comparable used machine?

Yes. With our procurement support we search specifically for a suitable used vacuum homogenizing mixer. Tell us your product, required volume, viscosity and requirements such as GMP, CIP/SIP or explosion protection – by phone at +49 4203 789492 or by email to info@s-vt.net.

This is a non-binding offer from SEEFRIED Verfahrenstechnik GmbH as an independent supplier.
There is no business relationship with the manufacturer.

All trademarks mentioned are the property of their respective owners and are used solely for the purpose of identifying the products offered.

This is not an offer from the manufacturer.