In the industrial production of injection solutions, solid and liquid substances are often mixed to create a solution for direct use. The active ingredients are often in powder form, while the other substances are mostly liquid.
Requirements for the homogenising mixer
Modern homogenising mixers must enable sterile and fast production. They also need optimal options for controlling and monitoring the processes as well as precise documentation of all production steps.
- pressure- and vacuum-resistant design
- installation options for additional measuring units, e.g. particle size measurement
- production according to complex recipe specifications
- aseptic valves and GMP-compliant design
Freedom from particles and product quality
The number of airborne particles must be kept as low as possible. Only a solution free of suspended particles can be filtered down to a certain particle size – and this is a prerequisite for high-quality injection solutions.
With identical design and performance of laboratory and production machines, precise scale-up with consistently high product quality is also achieved. Thanks to aseptic valves and GMP-compliant design, homogenising mixers can be used flexibly for almost all pharmaceuticals – from liquid to semi-solid.
FAQ: Producing injection solutions
How are injection solutions produced?
Powdered active ingredients are dissolved in liquid carriers, the solution is adjusted, sterile-filtered or produced aseptically and filled into ampoules, vials or syringes.
Which mixer is suitable for injection solutions?
Pressure and vacuum rated homogenising mixers in GMP design with aseptic valves, vacuum powder induction and connections for measuring instruments.
Why is freedom from particles so important?
Particles in parenterals are a safety risk. In-process measurement and sterile filtration ensure that limits are met.
How is a reliable scale-up achieved?
With laboratory and production machines of the same design and performance layout, so recipes and parameters can be transferred directly.
Does SEEFRIED supply plants for parenterals?
Yes, we plan and qualify plants for injection and infusion solutions and offer suitable homogenising mixers.