In the manufacture of pharmaceutical pastes, base substances and active ingredients are combined to form a stable, durable and effective finished preparation. These pastes are intended for external use.
Effect and composition
Many pharmaceutical pastes dry out wounds and have a secretion-binding and antiseptic effect. To achieve this, active ingredients and other ingredients of different consistencies are combined.
The components are often in powder form at the start. During production they must be dispersed or dissolved so that a finely distributed dispersion is formed with the other ingredients. Depending on the product, the solids content is between 25% and 50%.
Requirements for the manufacturing plant
In addition to hygienic production, the handling of substances of different viscosities is decisive. Modern plants can be used flexibly and efficiently for this:
- Homogenising in the vessel or in the circulation process
- Infinitely variable speed adjustment for efficient yet gentle processing
- Powder induction under vacuum for a high solids content
- Hygienic, GMP-compliant design with CIP cleaning
FAQ: Manufacturing pharmaceutical pastes
What distinguishes pastes from ointments?
Pastes are semi-solid preparations with a high solids content (typically 25 to 50%), e.g. zinc oxide. They adhere well, dry out wounds and bind secretions.
How are high powder contents incorporated?
Powders are drawn in gradually under vacuum and dispersed with a rotor-stator homogeniser until a fine, agglomerate-free distribution is achieved.
Which machine is suitable for pastes?
Vacuum homogenising mixers with a powerful scraper agitator, a homogeniser in the vessel or in circulation and infinitely variable speed for highly viscous products.
How are air inclusions avoided?
Through processing and deaeration under vacuum and a low speed during powder induction.
Does SEEFRIED supply plants for pastes?
Yes, SEEFRIED Verfahrenstechnik designs plants for semi-solid dosage forms and offers inspected used vacuum homogenising mixers.