In the manufacture of suspensions, components of different viscosities are combined. Since solids and liquids have very different properties, the requirements for the mixing process also vary greatly.
Efficient incorporation of solids
Homogenising mixers offer solutions for most applications. Thanks to special processes for dispersing powdered raw materials, solids can be handled easily and with as little dust as possible.
Powerful process plants also allow targeted addition of the raw materials. This speeds up the process, shortens production and cleaning times and increases production capacity.
Requirements for the plant
For the production of suspensions the plant should offer flexible and highly efficient agitating and homogenising properties. The following are particularly important:
- Introduction of powders below the liquid level
- Optimum powder wetting
- Breaking up of agglomerates and individual particles
- Optional particle size measurement to monitor and assure product quality
- Permanently lid-mounted CIP cleaning, optional spray heads on the agitator and sterilisation (SIP)
Particle size measurement helps to keep the number of airborne particles as low as possible. This freedom from suspended particles is a prerequisite for filtering particles up to a certain size out of the suspension.
FAQ: Manufacturing suspensions
What is a pharmaceutical suspension?
A suspension is a dispersion of solid, insoluble active ingredient particles in a liquid, e.g. antibiotic syrups or antacids. Fine particle size, redispersibility and dosing accuracy are decisive.
How are powders incorporated without lumps?
Through dust-free powder induction under vacuum directly below the liquid level into the rotor-stator homogeniser. This wets every particle and breaks up agglomerates.
How does a suspension remain stable?
Through small, uniform particles, suitable thickeners and wetting agents, and homogeneous distribution. In-process particle size measurement assures quality.
Which machine is suitable for suspensions?
Homogenising mixers with a scraper agitator, a homogeniser in the vessel or in circulation, vacuum operation as well as CIP and SIP.
Does SEEFRIED offer plants for suspensions?
Yes, SEEFRIED Verfahrenstechnik designs plants for pharmaceutical suspensions and supplies inspected used homogenising mixers.