The CIP - process (Cleaning in Place) comprises a range of mechanical and chemical processes, mainly used in the pharmaceutical, cosmetic and food industries. During CIP cleaning, vessels, pipelines and valves are cleaned between the individual production runs on the product-contacted surfaces, without these having to be dismantled beforehand. Practical experience and experiments have shown that the mechanical cleaning effect of mechanical cleaning solutions is influenced by the flow rate and turbulence of the cleaning liquid. The temperature and concentration of the cleaning solution are other factors which influence the cleaning speed and must be considered when designing a cleaning system. The CIP process plays a key role in ensuring product safety and hygiene, minimizing downtime while maximizing plant efficiency. Particular attention is paid here to the rising costs for water, energy and an optimized consumption of chemicals, which must be adapted to the individual products to be cleaned. For the development of cleaning processes, it is important to know the properties of excipients and active substances, in order to make a suitable choice of cleaning agents. Sometimes the false selection of detergent can significantly extend the cleaning time or prevent a complete cleaning. The degree of cleaning is dependent on many factors- Besides the type of contamination, the properties of the product-contacted surfaces, their installations, corners, edges, sealing configurations, low-flow/stagnant zones, e.g. in T - pieces, puddles and domes, as well as their operation conditions, play a decisive role.
The effectiveness of a cleaning is dependent on
- Design features of the plant area to be cleaned (GMP - Good Manufacturing Practice)
- Suitable material selection and material properties
- Suitable cleaning agent
- Proper cleaning conditions