Active Substance Deagglomeration

In the production of pharmaceutical products, agglomerates are often formed in the preliminary stages of the constituents, especially in the case of mixtures of powders and liquids. For the further production process, these agglomerates, or lumps, must be dissolved; the raw materials are to be comminuted. This procedure is referred to as active substance deagglomeration. A conventional agitator cannot cope with this task alone.  

Modern process plants with integrated high-performance agitator and homogenising systems are ideally suited for deagglomeration of active substances.  With their rotor/stator system, these homogenising mixers ensure optimum comminution of solid substances while at the same time increasing the surface area of the powder in the liquid. Agglomerate-free solutions are thus created in a few minutes. With the micronisation of pharmaceutical substances, not only a rapid dissolving of lumps is achieved, but also a greatly increased bioavailability of the active substances as a result of the enlargement of the particle surfaces during the procedure in the homogenising mixer. The improved bioavailability of the active substances achieves faster action of the drug substances, reduces the required quantity of the API and enables preparation of pharmaceutical products with fewer risks and side-effects for the patients.